Preparation of polysubstituted isochromanes by addition of ortho-lithiated aryloxiranes to enaminones.
نویسندگان
چکیده
The reaction of ortho-lithiated aryloxiranes with various enaminones straightforwardly affords new functionalized isochromanes as mixtures of two epimeric stereoisomers in reasonable to very good yields (50-90%). The two diastereomers, which show a high structural variability, can be easily separated by column chromatography.
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ورودعنوان ژورنال:
- The Journal of organic chemistry
دوره 78 21 شماره
صفحات -
تاریخ انتشار 2013